Pedley Research Group | Biochemistry and Molecular Biology

The Pedley Research Group

The Pedley Research Group strives to understand how metabolic enzymes are organized and regulated in human cells and the extent that disruption of these processes drive disease. We leverage a combination of biochemical, biophysical, genetic, and microscopy-based approaches to understand the complexity of supramolecular protein assemblies and the subtle nuances that drive selectivity in protein recruitment. We endeavor to use these findings to develop innovative therapeutic strategies targeting metabolic enzymes that alter biomolecular condensate properties and induce their degradation.

Lab News

2026

Tony presents the history of the purinosome and current lab's directions at the Holden Comprehensive Cancer Center Research Seminar Series (May).
Austin Harmsen joins the lab as a Graduate Research Assistant (May).
Tony delivers the keynote address at the Molecular Mechanisms of Disease Predoctoral Training Annual Symposium at the University of Nebraska-Lincoln (April).
Sang Bui joins the lab as a Research Assistant (February).
Tony presents the lab's work at Grand Valley State University (February).
Our first paper at Iowa was published in Proc Natl Acad Sci USA. Congratulations to Tim and our collaborators at Penn State University (Ruobo Zhou and Stephen Benkovic) (January).
Rachel Rethwisch, Tim Iles, and Alex Galindo presented their recent findings at the 31st Midwest Stress Response and Molecular Chaperone meeting at Northwestern (January).
The Lab welcomes Luke Brownell as an Undergraduate Research Assistant (January).
The Lab welcomes Lucia Simonicova as an Assistant Research Scientist (January).