Manuscripts

Since Joining The University of Iowa (2025 - present)

Year		Citation	Additional Data
2025	19	Boylan, J.P., Iles, T.D., Nguyen, A., Pedley, A.M. Enzyme Assemblies in Nucleotide Metabolism: Structure, Regulation, and Disease Implications. In: Pedley, A.M. (ed) Supramolecular Protein Assemblies in Cells. Advances in Experimental Medicine and Biology. Springer Nature. Anticipated Publication Date: Fall 2025.

Prior to Joining The University of Iowa (2013 - 2024)

Year		Citation	Additional Data
2023	18	Binder, M.J.; Pedley, A.M., The Roles of Molecular Chaperones in Regulating Cell Metabolism. FEBS Lett 2023, 597(13), 1681-1701.
2022	17	Pedley, A. M.; Pareek, V.; Benkovic, S. J., The Purinosome: A Case Study for a Mammalian Metabolon. Annu Rev Biochem 2022, 91, 89-106.
	16	Pedley, A. M.; Boylan, J. P.; Chan, C. Y.; Kennedy, E. L.; Kyoung, M.; Benkovic, S. J., Purine biosynthetic enzymes assemble into liquid-like condensates dependent on the activity of chaperone protein HSP90. J Biol Chem 2022, 298 (5), 101845.
2021	15	Pareek, V.; Pedley, A. M.; Benkovic, S. J., Human de novo purine biosynthesis. Crit Rev Biochem Mol Biol 2021, 56 (1), 1-16.
2020	14	Doigneaux, C.; Pedley, A. M.; Mistry, I. N.; Papayova, M.; Benkovic, S. J.; Tavassoli, A., Hypoxia drives the assembly of the multienzyme purinosome complex. J Biol Chem 2020, 295 (28), 9551-9566.
2019	13	Liu, C.; Knudsen, G. M.; Pedley, A. M.*; He, J.; Johnson, J. L.; Yaron, T. M.; Cantley, L. C.; Benkovic, S. J., Mapping Post- Translational Modifications of de Novo Purine Biosynthetic Enzymes: Implications for Pathway Regulation. J Proteome Res 2019, 18 (5), 2078-2087.
	12	Hedglin, M.; Aitha, M.; Pedley, A.; Benkovic, S. J., Replication protein A dynamically regulates monoubiquitination of proliferating cell nuclear antigen. J Biol Chem 2019, 294 (13), 5157-5168.
2018	11	Pedley, A. M.; Karras, G. I.; Zhang, X.; Lindquist, S.; Benkovic, S. J., Role of HSP90 in the Regulation of de Novo Purine Biosynthesis. Biochemistry 2018, 57 (23), 3217-3221.
	10	Chan, C. Y.; Pedley, A. M.; Kim, D.*; Xia, C.; Zhuang, X.; Benkovic, S. J., Microtubule-directed transport of purine metabolons drives their cytosolic transit to mitochondria. Proc Natl Acad Sci U S A 2018, 115 (51), 13009-13014.
	9	Pedley, A. M.; Benkovic, S. J., Detecting Purinosome Metabolon Formation with Fluorescence Microscopy. Methods Mol Biol 2018, 1764, 279-289.
2017	8	Pedley, A. M.; Benkovic, S. J., A New View into the Regulation of Purine Metabolism: The Purinosome. Trends Biochem Sci 2017, 42 (2), 141-154.
	7	Bartolowits, M. D.; Brown, W.; Ali, R.; Pedley, A. M.; Chen, Q.; Harvey, K. E.; Wendt, M. K.; Davisson, V. J., Selective Inhibition of STAT3 Phosphorylation Using a Nuclear-Targeted Kinase Inhibitor. ACS Chem Biol 2017, 12 (9), 2371-2378.
2016	6	French, J. B.; Jones, S. A.; Deng, H.; Pedley, A. M.; Kim, D.; Chan, C. Y.; Hu, H.; Pugh, R. J.; Zhao, H.; Zhang, Y.; Huang, T. J.; Fang, Y.; Zhuang, X.; Benkovic, S. J., Spatial colocalization and functional link of purinosomes with mitochondria. Science 2016, 351 (6274), 733-7.
	5	Zhao, H.; Chiaro, C. R.; Zhang, L.; Smith, P. B.; Chan, C. Y.; Pedley, A. M.; Pugh, R. J.; French, J. B.; Patterson, A. D.; Benkovic, S. J., Quantitative analysis of purine nucleotides indicates that purinosomes increase de novo purine biosynthesis. J Biol Chem 2015, 290 (11), 6705-13.
	4	Witucki, L. A.; Borowicz, L. S.; Pedley, A. M.; Curtis-Fisk, J.; Kuszpit, E. G., Identification of FAK substrate peptides via colorimetric screening of a one-bead one-peptide combinatorial library. J Pept Sci 2015, 21 (4), 302-11.
2015	3	Chan, C. Y.; Zhao, H.; Pugh, R. J.; Pedley, A. M.; French, J.; Jones, S. A.; Zhuang, X.; Jinnah, H.; Huang, T. J.; Benkovic, S. J., Purinosome formation as a function of the cell cycle. Proc Natl Acad Sci U S A 2015, 112 (5), 1368-73.
	2	Pedley, A. M.; Lill, M. A.; Davisson, V. J., Flexibility of PCNA-protein interface accommodates differential binding partners. PLoS One 2014, 9 (7), e102481.
2014	1	Oliver, J. C.; Gudihal, R.; Burgner, J. W.; Pedley, A. M.; Zwierko, A. T.; Davisson, V. J.; Linger, R. S., Conformational changes involving ammonia tunnel formation and allosteric control in GMP synthetase. Arch Biochem Biophys 2014, 545, 22-32.